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1.

Antibody homotypic interactions are encoded by germline light chain complementarity determining region 2.

Leonard, Brandon; Sankar, Kannan; Romei, Matthew G; Tse, Margaret J; Do, Nina; Yang, Yanli; Matochko, Wadim L; Bevers, Jack; Bollineni, Sundeep; Mukhyala, Kiran; Hoi, Kam Hon; Lazar, Greg A.

Proc Natl Acad Sci U S A ; 119(23): e2201562119, 2022 06 07.

Article in English | MEDLINE | ID: mdl-35653561

2.

Antibody-guided proteases enable selective and catalytic degradation of challenging therapeutic targets.

Romei, Matthew G; Leonard, Brandon; Kim, Ingrid; Kim, Hok Seon; Lazar, Greg A.

J Biol Chem ; 299(5): 104685, 2023 05.

Article in English | MEDLINE | ID: mdl-37031819

3.

Characterizing and Quantitating Therapeutic Tethered Multimeric Antibody Degradation Using Affinity Capture Mass Spectrometry.

Li, Wenjing; Srikumar, Neha; Forrest, William F; Ellerman, Diego; Gu, Chen; Tchelepi, Robert; Lazar, Greg A; Liu, Yichin; Tran, John C.

Anal Chem ; 92(10): 6839-6843, 2020 05 19.

Article in English | MEDLINE | ID: mdl-32309925

4.

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry.

Park, Hae-Min; Winton, Valerie J; Drader, Jared J; Manalili Wheeler, Sheri; Lazar, Greg A; Kelleher, Neil L; Liu, Yichin; Tran, John C; Compton, Philip D.

Anal Chem ; 92(2): 2186-2193, 2020 01 21.

Article in English | MEDLINE | ID: mdl-31880920

5.

Susceptibility of Antibody CDR Residues to Chemical Modifications Can Be Revealed Prior to Antibody Humanization and Aid in the Lead Selection Process.

Xu, Ankai; Kim, Hok Seon; Estee, Samarkand; ViaJar, Sharon; Galush, William J; Gill, Avinash; Hötzel, Isidro; Lazar, Greg A; McDonald, Paul; Andersen, Nisana; Spiess, Christoph.

Mol Pharm ; 15(10): 4529-4537, 2018 10 01.

Article in English | MEDLINE | ID: mdl-30118239

6.

Attachment Site Cysteine Thiol pK_a Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody-Drug Conjugates.

Vollmar, Breanna S; Wei, Binqing; Ohri, Rachana; Zhou, Jianhui; He, Jintang; Yu, Shang-Fan; Leipold, Douglas; Cosino, Ely; Yee, Sharon; Fourie-O'Donohue, Aimee; Li, Guangmin; Phillips, Gail L; Kozak, Katherine R; Kamath, Amrita; Xu, Keyang; Lee, Genee; Lazar, Greg A; Erickson, Hans K.

Bioconjug Chem ; 28(10): 2538-2548, 2017 10 18.

Article in English | MEDLINE | ID: mdl-28885827

7.

Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function.

Tai, Yu-Tzu; Horton, Holly M; Kong, Sun-Young; Pong, Erik; Chen, Hsing; Cemerski, Saso; Bernett, Matthew J; Nguyen, Duc-Hanh T; Karki, Sher; Chu, Seung Y; Lazar, Greg A; Munshi, Nikhil C; Desjarlais, John R; Anderson, Kenneth C; Muchhal, Umesh S.

Blood ; 119(9): 2074-82, 2012 Mar 01.

Article in English | MEDLINE | ID: mdl-22246035

8.

T cell-Dependent Bispecific Therapy Enhances Innate Immune Activation and Antibody-Mediated Killing.

Besla, Rickvinder; Penuel, Elicia; Del Rosario, Geoff; Cosino, Ely; Myrta, Szymon; Dillon, Mike; Lazar, Greg A; Nickles, Dorothee; Spiess, Christoph; Yu, Shang-Fan; Polson, Andrew G.

Cancer Immunol Res ; 12(1): 60-71, 2024 01 03.

Article in English | MEDLINE | ID: mdl-37902604

9.

i-shaped antibody engineering enables conformational tuning of biotherapeutic receptor agonists.

Romei, Matthew G; Leonard, Brandon; Katz, Zachary B; Le, Daniel; Yang, Yanli; Day, Eric S; Koo, Christopher W; Sharma, Preeti; Bevers Iii, Jack; Kim, Ingrid; Dai, Huiguang; Farahi, Farzam; Lin, May; Shaw, Andrey S; Nakamura, Gerald; Sockolosky, Jonathan T; Lazar, Greg A.

Nat Commun ; 15(1): 642, 2024 Jan 20.

Article in English | MEDLINE | ID: mdl-38245524

10.

Modulation of antibody effector function.

Desjarlais, John R; Lazar, Greg A.

Exp Cell Res ; 317(9): 1278-85, 2011 May 15.

Article in English | MEDLINE | ID: mdl-21459085

11.

Avidity in antibody effector functions and biotherapeutic drug design.

Oostindie, Simone C; Lazar, Greg A; Schuurman, Janine; Parren, Paul W H I.

Nat Rev Drug Discov ; 21(10): 715-735, 2022 10.

Article in English | MEDLINE | ID: mdl-35790857

12.

Antibody interfaces revealed through structural mining.

Yin, Yizhou; Romei, Matthew G; Sankar, Kannan; Pal, Lipika R; Hoi, Kam Hon; Yang, Yanli; Leonard, Brandon; De Leon Boenig, Gladys; Kumar, Nikit; Matsumoto, Marissa; Payandeh, Jian; Harris, Seth F; Moult, John; Lazar, Greg A.

Comput Struct Biotechnol J ; 20: 4952-4968, 2022.

Article in English | MEDLINE | ID: mdl-36147680

13.

Fc-engineered EGF-R antibodies mediate improved antibody-dependent cellular cytotoxicity (ADCC) against KRAS-mutated tumor cells.

Schlaeth, Martin; Berger, Sven; Derer, Stefanie; Klausz, Katja; Lohse, Stefan; Dechant, Michael; Lazar, Greg A; Schneider-Merck, Tanja; Peipp, Matthias; Valerius, Thomas.

Cancer Sci ; 101(5): 1080-8, 2010 May.

Article in English | MEDLINE | ID: mdl-20331636

14.

Targeted IgMs agonize ocular targets with extended vitreal exposure.

Chen, Yvonne; Paluch, Maciej; Zorn, Julie A; Rajan, Sharmila; Leonard, Brandon; Estevez, Alberto; Brady, John; Chiu, Henry; Phung, Wilson; Famili, Amin; Yan, Minhong; Ciferri, Claudio; Matsumoto, Marissa L; Lazar, Greg A; Crowell, Susan; Hass, Phil; Agard, Nicholas J.

MAbs ; 12(1): 1818436, 2020.

Article in English | MEDLINE | ID: mdl-32936727

15.

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies.

Chu, Seung Y; Vostiar, Igor; Karki, Sher; Moore, Gregory L; Lazar, Greg A; Pong, Erik; Joyce, Patrick F; Szymkowski, David E; Desjarlais, John R.

Mol Immunol ; 45(15): 3926-33, 2008 Sep.

Article in English | MEDLINE | ID: mdl-18691763

16.

Optimization of antibody binding to FcgammaRIIa enhances macrophage phagocytosis of tumor cells.

Richards, John O; Karki, Sher; Lazar, Greg A; Chen, Hsing; Dang, Wei; Desjarlais, John R.

Mol Cancer Ther ; 7(8): 2517-27, 2008 Aug.

Article in English | MEDLINE | ID: mdl-18723496

17.

An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans.

Chung, Shan; Nguyen, Van; Lin, Yuwen Linda; Lafrance-Vanasse, Julien; Scales, Suzie J; Lin, Kevin; Deng, Rong; Williams, Kathi; Sperinde, Gizette; Li, Juan Jenny; Zheng, Kai; Sukumaran, Siddharth; Tesar, Devin; Ernst, James A; Fischer, Saloumeh; Lazar, Greg A; Prabhu, Saileta; Song, An.

MAbs ; 11(5): 942-955, 2019 07.

Article in English | MEDLINE | ID: mdl-30982394

18.

Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members.

Yang, Yanli; Yeh, Sherry H; Madireddi, Shravan; Matochko, Wadim L; Gu, Chen; Pacheco Sanchez, Patricia; Ultsch, Mark; De Leon Boenig, Gladys; Harris, Seth F; Leonard, Brandon; Scales, Suzie J; Zhu, Jing W; Christensen, Erin; Hang, Julie Q; Brezski, Randall J; Marsters, Scot; Ashkenazi, Avi; Sukumaran, Siddharth; Chiu, Henry; Cubas, Rafael; Kim, Jeong M; Lazar, Greg A.

MAbs ; 11(6): 996-1011, 2019.

Article in English | MEDLINE | ID: mdl-31156033

19.

A molecular immunology approach to antibody humanization and functional optimization.

Lazar, Greg A; Desjarlais, John R; Jacinto, Jonathan; Karki, Sher; Hammond, Philip W.

Mol Immunol ; 44(8): 1986-98, 2007 Mar.

Article in English | MEDLINE | ID: mdl-17079018

20.

Next generation antibody drugs: pursuit of the 'high-hanging fruit'.

Carter, Paul J; Lazar, Greg A.

Nat Rev Drug Discov ; 17(3): 197-223, 2018 03.

Article in English | MEDLINE | ID: mdl-29192287

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